Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases


There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes and berries, may confer
a protective effect against aging-related diseases and protection against oxidative stress.

Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer’s disease (AD). In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired.  

As an individual ages, the balance between a long, healthy lifespan and suffering age-related diseases is believed to be related to the interplay between the cellular antioxidant defence system and adverse effects related to oxidative stress.

In aging cells, oxidative stress increases due to a progressive decline in the efficiency of antioxidant defence systems. There is convincing evidence to indicate that supplementation with polyphenols, such as stilbenes, anthocyanins, and catechins, can increase cellular antioxidant defence and promote health of the individual. 

Oxidative Medicine and Cellular Longevity  DOI10.1155/2015/340520

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